Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine

Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine

The Maximum Flux of Star-Forming Galaxies

The importance of radiation pressure feedback in galaxy formation has been extensively debated over the last decade. The regime of greatest uncertainty is in the most actively star-forming galaxies, where large dust columns can potentially produce a dust-reprocessed infrared radiation field with enough pressure to drive turbulence or eject material. Here we derive the conditions under which a self-gravitating, mixed gas-star disc can remain hydrostatic despite trapped radiation pressure. Consistently taking into account the self-gravity of the medium, the star- and dust-to-gas ratios, and the effects of turbulent motions not driven by radiation, we show that galaxies can achieve a maximum Eddington-limited star formation rate per unit area $\dot{\Sigma}_{\rm *,crit} \sim 10^3 M_{\odot}$ pc$^{-2}$ Myr$^{-1}$, corresponding to a critical flux of $F_{\rm *,crit} \sim 10^{13} L_{\odot}$ kpc$^{-2}$ similar to previous estimates; higher fluxes eject mass in bulk, halting further star formation. Conversely, we show that in galaxies below this limit, our one-dimensional models imply simple vertical hydrostatic equilibrium and that radiation pressure is ineffective at driving turbulence or ejecting matter. Because the vast majority of star-forming galaxies lie below the maximum limit for typical dust-to-gas ratios, we conclude that infrared radiation pressure is likely unimportant for all but the most extreme systems on galaxy-wide scales. Thus, while radiation pressure does not explain the Kennicutt-Schmidt relation, it does impose an upper truncation on it. Our predicted truncation is in good agreement with the highest observed gas and star formation rate surface densities found both locally and at high redshift.Comment: Version accepted for publication in MNRAS. 12 pages, 8 figures. New appendix on photon tirin

Abnormal depth perception from motion parallax in amblyopic observers

AbstractMany similarities exist between the perception of depth from binocular stereopsis and that from motion parallax. Moreover, Rogers (1984, cited in, Howard, I. P., & Rogers, B. J. (1995). Binocular vision and stereopsis. Oxford Claridon, New York.) suggests a relationship between an observer’s ability to use disparity information and motion parallax information in a depth perception task. To more closely investigate this relationship, depth perception was studied in normal observers and amblyopic observers with poor stereo vision. As expected, amblyopic observers performed much worse than normal observers on depth discriminations requiring use of binocular disparity. However, amblyopic observers also performed much worse than normal observers on depth discriminations based on motion parallax. This result provides supporting evidence for a psychoanatomical link between the perception of depth from motion and the perception of depth from binocular disparity

Performance of Spatial Modulation using Measured Real-World Channels

In this paper, for the first time real-world channel measurements are used to analyse the performance of spatial modulation (SM), where a full analysis of the average bit error rate performance (ABER) of SM using measured urban correlated and uncorrelated Rayleigh fading channels is provided. The channel measurements are taken from an outdoor urban multiple input multiple output (MIMO) measurement campaign. Moreover, ABER performance results using simulated Rayleigh fading channels are provided and compared with a derived analytical bound for the ABER of SM, and the ABER results for SM using the measured urban channels. The ABER results using the measured urban channels validate the derived analytical bound and the ABER results using the simulated channels. Finally, the ABER of SM is compared with the performance of spatial multiplexing (SMX) using the measured urban channels for small and large scale MIMO. It is shown that SM offers nearly the same or a slightly better performance than SMX for small scale MIMO. However, SM offers large reduction in ABER for large scale MIMO.Comment: IEEE Vehicular Technology Conference Fall 2013 (VTC-Fall 2013), Accepte

The Relationship Between Molecular Gas Tracers and Kennicutt-Schmidt Laws

We provide a model for how Kennicutt-Schmidt (KS) laws, which describe the correlation between star formation rate and gas surface or volume density, depend on the molecular line chosen to trace the gas. We show that, for lines that can be excited at low temperatures, the KS law depends on how the line critical density compares to the median density in a galaxy's star-forming molecular clouds. High critical density lines trace regions with similar physical properties across galaxy types, and this produces a linear correlation between line luminosity and star formation rate. Low critical density lines probe regions whose properties vary across galaxies, leading to a star formation rate that varies superlinearly with line luminosity. We show that a simple model in which molecular clouds are treated as isothermal and homogenous can quantitatively reproduce the observed correlations between galactic luminosities in far infrared and in the CO(1->0) and HCN(1->0) lines, and naturally explains why these correlations have different slopes. We predict that IR-line luminosity correlations should change slope for galaxies in which the median density is close to the line critical density. This prediction may be tested by observations of lines such as HCO^+(1->0) with intermediate critical densities, or by HCN(1->0) observations of intensely star-forming high redshift galaxies with very high densities. Recent observations by Gao et al. hint at just such a change in slope. We argue that deviations from linearity in the HCN(1->0)-IR correlation at high luminosity are consistent with the assumption of a constant star formation efficiency.Comment: Accepted to ApJ. 11 pages, 4 figures, emulateapj format. This version has some additional models exploring the effects of varying metallicity and temperature. The conclusions are unchange

Servo design and analysis for the Thirty Meter Telescope primary mirror actuators

The Thirty Meter Telescope has 492 primary mirror segments, each incorporated into a Primary Segment Assembly (PSA), each of which in turn has three actuators that control piston, tip, and tilt, for a total of 1476 actuators. Each actuator has a servo loop that controls small motions (nanometers) and large motions (millimeters). Candidate actuators were designed and tested that fall into the categories of "hard" and "soft," depending on the offload spring stiffness relative to the PSA structural stiffness. Dynamics models for each type of actuator are presented, which respectively use piezo-electric transducers and voice coils. Servo design and analysis are presented that include assessments of stability, performance, robustness, and control structure interaction. The analysis is presented for a single PSA on a rigid base, and then using Zernike approximations the analysis is repeated for 492 mirror segments on a flexible mirror cell. Servo requirements include low-frequency stiffness, needed for wind rejection; reduced control structure interaction, specified by a bound on the sensitivity function; and mid-frequency damping, needed to reduce vibration transmission. The last of these requirements, vibration reduction, was found to be an important distinguishing characteristic for actuator selection. Hard actuators have little inherent damping, which is improved using PZT shunt circuits and force feedback, but still these improvements were found to result in less damping than is provided by the soft actuator. Results of the servo analysis were used for an actuator down-select study

Control analysis of the TMT primary segment assembly

The primary mirror control system (M1CS) stabilizes the 492 segments of the Thirty Meter Telescope primary mirror in the presence of disturbances. Each Primary Segment Assembly (PSA) has three actuators and position sensors that control the piston, tip, and tilt of the mirror segment. Requirements for the PSA position controller are presented, with the main requirements being 10 Newton per micron stiffness below one Hertz, where wind is the primary disturbance. Bandwidths of the PSA position controller of about twenty Hertz, assuming a soft actuator, are needed to meet this requirement. A finite element model of the PSA was developed and used for a preliminary control design. PSA structural modes at 40, 90, and 120 impact the control design. We have studied control designs with different actuators, sensors, and structural filters in order to assess disturbance rejection properties and interactions with the PSA structural modes. The performance requirements are achieved using voice coil actuators with modal control architecture for piston, tip, and tilt. Force interactions with the underlying mirror cell are important, and we present the status of our studies of the control structure interaction effect (CSIE). A related paper presents further analysis of the CSIE and MICS global position control loop

Analysis of the TMT mount control system

The TMT mount control system provides telescope pointing and tracking. Requirements include wind disturbance rejection, offsetting time and accuracy, control system robustness, and the magnitude of response at structural resonances. A finite element model of the complete telescope has been developed and the transfer functions used for the control designs are presented. Wind disturbance, encoder, and wave-front-sensor models are presented that are used for the control design. A performance analysis translates the requirements to a required bandwidth. Achieving this bandwidth is important for reducing telescope image motion due to wind-buffeting. A mount control design is presented that meets the demanding requirements by maximizing low frequency gain and using structural filters to roll-off structural modes. The control system analysis includes an outer guide loop using a wave front sensor. Offsetting time and accuracy requirements are satisfied using feed-forward control architecture

Lack of analgesic efficacy in female rats of\ud the commonly recommended oral dose of\ud buprenorphine

Previous work in our laboratory showed that the recommended oral dose of buprenorphine (0.5 mg/kg) was not as effective\ud as the standard therapeutic subcutaneous dose for postoperative analgesia in male Long-Evans (hooded) and Sprague-Dawley (albino) rats. The aim of the current study was to extend this analysis to female rats. We measured the pain threshold in adult female rats in diestrus or proestrus before and 30 and 60 min after oral buprenorphine (0.5 mg/kg,), the standard subcutaneous dose of buprenorphine (0.05 mg/kg), or vehicle only (1 ml/kg each orally and subcutaneously). Female rats showed an increased pain threshold (analgesia) after subcutaneous buprenorphine but no change in pain threshold after either oral buprenorphine or vehicle only. Estrous cycle stage (proestrus versus diestrus) did not affect the analgesic effects of buprenorphine, but rats in proestrus showed significantly lower pain thresholds (less tolerance to pain) than did those in diestrus. These results show that the oral dose of buprenorphine recommended for postoperative analgesic care does not induce significant analgesia in female rats and therefore is not as effective as the standard subcutaneous dose